Animator, independent filmmaker, writer, flipbook artist, film producer, George Griffin came from Tennessee to New York City in 1967. He drew one cartoon for RAW and one for RAT, apprenticed at an animation studio for one year, and was an assistant animator on Fritz the Cat for one month. Concurrently, influenced by the work of Robert Breer and Saul Steinberg, he was experimenting in various media and techniques, and in 1969 completed his first film. Griffin has made over 30 personal films from 10 seconds to 30 minutes long, which have been seen on television, in theaters, at festivals and museums worldwide; most can be streamed at vimeo.com/geogrif. His early interactive film installation work (Franklin Furnace, Artists Space) has evolved into construction of "digital mutoscopes" such as Viewmaster (2010 Site Santa Fe Biennial).  

He has produced and directed educational, documentary, graphic segments, and advertising spots for TV, and was line-producer of R.O. Blechman's The Soldier's Tale for PBS. Griffin has taught at Harvard, Pratt, Parsons, Hunter, NYU, SVA; has been a visiting artist at KASK (Ghent), CAFA (Beijing), and NanJing (Singapore); and has served on panels at film festivals (Ottawa, Stuttgart, Poznan, Utrecht, Portland).

Griffin's essays and reviews have appeared in Film Comment, Pervasive Animation, Cartoons, EnterText, the International Journal of Animation, and other publications, often under catchy titles like “Concrete Animation,” “Cartoon, Anti-Cartoon, ”The Anxious Pencil,” "Take the B Train,” and “Furniture of My Mind.” His publishing projects include Frames: Drawings and Statements by Independent Animators, Flip-Pack, a boxed set of flipbooks by six contemporary animators, as well as numerous editions of flipbooks which were exhibited at Daumenkino (2005, Dusseldorf Kunsthalle).

Griffin has received grants from Guggenheim, the NEA, and NYSCA; his films and drawings are in the collection of MoMA, which has recently restored Lineage . Griffin made Head and Flying Fur at MacDowell and has also made a satirical User's Manual honoring the residence's Centennial.